Keywords

• Methotrexate hydrate
• L-Glutamicacid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• N-(4-((2,4-Diamino-6-pteridinyl)methylamino)benzoyl)-L-glutamic acid

Quick Details

• ProName: Factory Supply Methotrexate hydrate
• CasNo: 59-05-2
• Molecular Formula: C20H22N8O5
• Appearance: solid
• Application: Pharmaceutical intermediates
• DeliveryTime: immediately
• PackAge: Aluminum Foil Bag
• Port: Shanghai Port
• ProductionCapacity: 5 Kilogram/Day
• Purity: 99%
• Storage: keep in cool and dry place
• Transportation: by Fedex or DHL (door to door)
• LimitNum: 1 Gram
• Moisture Content: 10%max
• Residual Solvent: 0
• Heavy Metal: 0
• purity: 99%

Superiority

Methotrexate Basic information

Treatment of cancer and rheumatoid arthritis History of discovery Immunosuppressants Pharmacological effects Pharmacokinetics Clinical application Dosage Adverse reactions and precautions Drug Interactions Chemical Properties Production method

Product Name: Methotrexate

Synonyms: METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe

CAS: 59-05-2

MF: C20H22N8O5

MW: 454.44

EINECS: 200-413-8

Product Categories: Inhibitor;Anti-cancer&immunity;API;Aromatics;Bases & Related Reagents;Chiral Reagents;Heterocycles;Nucleotides;Antitumour;Aromatic Esters;API's;Antibiotics for Research and Experimental Use;Antitumors for Research and Experimental Use;Biochemistry;Others (Antibiotics for Research and Experimental Use);Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors

Mol File: 59-05-2.mol

Methotrexate Structure

Methotrexate Chemical Properties

Melting point 195°C

alpha +17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)

Boiling point 561.26°C (rough estimate)

density 1.4080 (rough estimate)

refractive index 1.6910 (estimate)

Fp 11℃

storage temp. −20°C

solubility H2O: insoluble

form powder

pka pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)

Water Solubility Insoluble. <0.1 g/100 mL at 19 ºC

Sensitive Light Sensitive & Hygroscopic

Merck 14,5985

BRN 70669

Stability: Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.

InChIKey FBOZXECLQNJBKD-ZDUSSCGKSA-N

CAS DataBase Reference 59-05-2(CAS DataBase Reference)

IARC 3 (Vol. 26, Sup 7) 1987

NIST Chemistry Reference Methotrexate(59-05-2)

EPA Substance Registry System Methotrexate (59-05-2)

Details

Ality Chemical, established in 2007, is a comprehensive Chemical Production&Supply Group with Patent Technology as its core. Ality Chemical operates sales branches in Shanghai, Xiamen and Hongkong, including production bases in Xinjiang(90,000 square meters), Hebei(40,000 square meters), Jiangsu(36,000 square meters) and Fujian(31,000 square meters) provinces.

Ality Chemical mainly provides Life Science Series, Fine Intermediates, Chemical Additives and Custom Manufactures including OEM and R&D Services.

Ality Chemical devotes to providing global retail customers and end clients with quality, comprehensive and diversified chemicals.

Ality Chemical upholds the creed that, Employees as the base, Customer as the core, Market as the direction, and Compliance as the principle, which is committed to creating the leading Chemical Production&Supply Brand in the world.